New antiepileptic drugs. II. Clinical use

New antiepileptic drugs. II. Clinical use.

The new antiepileptic drugs: clinical applications.

In the past decade, 8 new antiepileptic drugs have been approved for use in the United States, offering many new treatment options to patients with epilepsy. With expanding use of these newer agents, primary care clinicians are challenged with understanding the roles that each new agent plays in the treatment of patients with epilepsy as well as possible interactions with other pharmacological ...

New antiepileptic drugs – an

The last ten years of the 20th century is called in neuroscience “decade of the brain”. This period has brought many new antiepileptic drugs (AEDs) to the practising physician. New AEDs include: vigabatrin, lamotrigine, topiramate, tiagabine, gabapentin, oxcarbazepine, levetiracetam and zonisamide (not registered in Poland). The development of these drugs was under the current epilepsy theory (...

Rickets Due To Prolonged Use of Antiepileptic Drugs

La therapeutique ant epileptique de longue duree provoque une profonde modification du metabolisme de la vitamine B et notamment une acceleration du catabolisme de celle-ci.  Les auteurs rapportent un cas de ce type particulier d'osteomalacie et la revue de la lit­terature leur permet de souligner trois points essentiels:  1 ) les besoins journaliers de la vitamine B sontaccrus chez les enfan...

Clinical pharmacology of parenteral use of antiepileptic drugs.

Intravenous (i.v.) administration of antiepileptic drugs (AEDs) produces the most rapid onset of action, as it is delivered directly into the bloodstream and immediately produces maximal plasma concentration (C0 = Cmax). In addition to its therapeutic value, i.v. administration is essential in investigating the pharmacokinetics (PK) or clinical pharmacology of drugs, as it bypasses absorption a...